Child-Centered: Future Focused
Learning Objectives Describe guideline recommendations for use of exclusive and supplemental parenteral nutrition in the critically ill adult. Sara Duytschaver is a ray of sunshine in our lives. With grid electricity unaffordable for industry and households having the rooftop option, the grid costs will be spread across a smaller consumer base. The circulation is mainly due to the Coriolis effect. John of Cloverdale, WA, Australia. The programs will also address continued treatment of malnourished individuals after discharge. The new unleashed Abbott is so much stronger, more compelling, and his message is being spread far and wide.
September 27, Dine Out For Education. October 5, No School. October 7, October 8, No School. October 9, 6: October 23, 6: November 13, 6: November 15, End of First Trimester 58 Days. November 16, No School. Dine Out for Education: Unanimous Approval for Amendment to Teacher and Paraeducator Negotiated Agreements The Iowa City Community School District is proud to announce the unanimous approval of an amendment to the teacher and paraeducator negotiated agreements by the School Board during their September 11, meeting.
Faces of the District. Weber Elementary's Marnie Saeugling Comments North Central's Karrie Merriweather Comments Penn Elementary's Jodi Krueger Comments Hoover Elementary's Lisa Holland Comments Borlaug Elementary's Meghan Meyer Comments City High's Anterio Nimmers Comments Kirkwood Elementary's Jeanine Kaufman Comments Twain Elementary's Randy Nguyen Comments Shimek Elementary's Victoria Mueller Comments West High's Megan Johnson Comments You eat some food.
In the early stages of food absorption both glucose and FFAs enter cells under the facilitation of insulin. They do this easily, the cells are "hungry". As an individual cell becomes replete it has to signal that it doesn't want any more metabolic substrate. This is achieved via the CoQ couple acting as the master sensor for metabolic energy status. Given a high delta psi ie minimal consumption of the proton motive force because ATP is already plentiful this CoQ reduction eventually facilitates RET through complex I to give superoxide generation in order to stop insulin signalling.
Which then limits cellular caloric ingress. This can be thought of as the "cellular satiety" signal. It is ROS generated. Let's say that again: Satiety in peripheral cells is an ROS signal. It is generated in the mitochondria.
This is pure Protons. Now let's scale that up. As more and more peripheral cells decide that they no longer need to respond to insulin then there is less and less of a "sump" available for absorbed calories to drop in to. The availability of calories which no longer have anywhere to go is the whole-body driver of the need to signal satiety.
These people have the correct sort of idea: Fuel utilization by hypothalamic neurons: Posted by Peter at Sunday, September 09, 2 comments: Insulin makes you hungry 7 superoxide is satiety. Thursday, August 23, Insulin makes you hungry 6 except when you snort it. The action of insulin is the inhibition of lipolysis. This is our next paper: Intranasal insulin does interesting things. I just wanted to run through the initial results following a single dose of 40iu of intranasal insulin and a subsequent successful!
These are the levels of insulin in cerebrospinal fluid CSF of volunteers as measured by sampling through a spinal catheter placed at the L4-L5 level ouch! Posted by Peter at Thursday, August 23, 7 comments: Insulin makes you hungry 6 except when you snort it. Tuesday, August 21, Another brief housekeeping post. I published the "awaiting moderation" comments.
Lots of them are insightful and need a response. Time for this is not looking good at the moment! Please feel free to re comment if you wish.
Posted by Peter at Tuesday, August 21, 2 comments: Insulin makes you hungry 5 except when you resist. The function of insulin is the inhibition of lipolysis. Does resisting insulin facilitate lipolysis? This the next paper: How can I already tell they are going to find that insulin suppresses appetite? End aside, sniggering excepted. The only parts I am interested in are the clamps and the appetite scores no food intakes in this one.
So we have a low insulin clamp and a high insulin clamp looking a lot like this: Friday, August 03, Holiday reading. I'm off on vacation for a while so the next posts are likely to be delayed. If anyone would like a light summary of the ideas I'm thinking about, this is a nice review: Yin and Yang of hypothalamic insulin and leptin signaling in regulating white adipose tissue metabolism For a level deeper of understanding you just need to add in that saturated fats have an FADH2: NADH ratio around 0.
NADH ratio of well below 0. Because a core function of insulin is the inhibition of lipolysis. Posted by Peter at Friday, August 03, 2 comments: Wednesday, August 01, Insulin makes you hungry 4 unless you keep it out of your brain. Especially via the brain. Where insulin detemir doesn't go. People will be aware that insulin detemir is really strange stuff. There are perfectly respectable papers showing that it cannot enter the brain and blocks the entry of normal insulin in to the brain too or that it is fantastic at entering the brain, much better than more normal insulins.
There are probably more studies in the latter camp but my biases push me towards the former camp. The nature of the researchers also tends to push me towards the former camp. I posted on insulin detemir here and here to explain my point of view. Now there is this paper: Just eyeballing the insulin doses used we can assume that the plasma insulin levels were a reasonable approximation for humans in the normal post prandial period, ie physiological fed-state rather than pharmacological.
The research group is completely wedded to the idea that central insulin is an appetite suppressant and that weight gain from any insulin therapy is only a reaction to recurrent hypoglycamia.
As there is no hypoglycaemia during the clamps their presumption is that this neutral insulin infusion results in a reduced food intake. As insulin detemir gives less food intake after a normoglycaemic clamp than neutral insulin does, then their conclusion is that insulin detemir is having a more potent central appetite suppressing effect than the neutral insulin.
They are so confident about this that the inclusion of a control situation, where saline was infused without any insulin and appetite was checked after this, was considered un-necessary.
This really is the level of research in the "satiety" insulin camp. Posted by Peter at Wednesday, August 01, 10 comments: Insulin makes you hungry 4 unless you keep it out of your brain. Monday, July 30, Insulin makes you hungry 3 a matter of semantics and free fatty acids. There is absolutely nothing technically incorrect with the description of the results contained within the title of this paper: Effects of insulin-induced hypoglycaemia on energy intake and food choice at a subsequent test meal They gave a small dose of insulin low enough to not need rescue glucose within the study period as a single bolus, waited for 20 minutes then offered the subjects an eat-as-much-as you-like buffet.
This is what the glucose levels did. Posted by Peter at Monday, July 30, 5 comments: Insulin makes you hungry 3 a matter of semantics and free fatty acids.
Tuesday, July 24, Insulin makes you hungry 2 even in the presence of hyperglycaemia. This is the paper cited by Woo: Posted by Peter at Tuesday, July 24, No comments: Insulin makes you hungry 1.
If you want to think about the central effects of insulin you could do a great deal worse than working through this paper: Brain insulin controls adipose tissue lipolysis and lipogenesis It is jammed full of exquisite quotes: Thus, at the doses administered, brain insulin infusion inhibited lipolysis to a similar extent as that achieved with peripheral hyperinsulinemia" Here it is in pictures.
What does a CNS infusion of insulin do to lipolysis, at what are purported to be physiological dose rates? Obviously, it does exactly what peripheral insulin does, but using minuscule amounts; it suppresses lipolysis: Posted by Peter at Tuesday, July 24, 3 comments: Sunday, July 22, Butter gives you fatty liver! This paper is an absolute gem: It contains no trace of understanding in its entirety, but the numbers in the results are fascinating.
How do we sum it up? If you pay people to over eat kcal per day for three weeks they gain weight and they gain liver fat. Posted by Peter at Sunday, July 22, 14 comments: Butter gives you fatty liver! Tuesday, July 17, Oops. OMG, just seen how many comments are awaiting moderation now I'm back to occasional posting. I'll see what I can do, if desperate I'll just delete the spam and hit post for them all.
Apologies for the inattention over the past few weeks Posted by Peter at Tuesday, July 17, No comments: Woo had a bit of a rant about acipimox. Here's my simplified idea. I've been interested in acipimox, in a round about sort of a way, for a very long time. Minor differences in style may appear in each publication, but the article is substantially the same in each journal.
Malone are members of the Steering Committee of the Alliance to Advance Patient Nutrition who have been chosen by the professional organizations they represent and reimbursed for Alliance-related expenses.